REVIEW: TOXICITY AND TOXICITY TESTING OF PERTUSSIS VACCINE

Pertussis Vaccine Testing for Freedom-from-toxicity.

The results of 9.5 years of official testing of vaccines containing pertussis vaccine, plain or adsorbed with alum, Al(OH)(3), or AlPO(4), are reported. Toxicity was evaluated by weight changes in mice at 3 and 7 days after injection and intercurrent deaths. Toxicity was encountered during the early use of AlPO(4) in pertussis vaccine products, with a special product and quadruple-antigen vacci...

Whole cell pertussis vaccine: reducing toxicity.

Since introduction of the pertussis vaccine in 1940's the morbidity and mortality due to the infection has been markedly reduced all over the world. However the adverse effects of the inactivated whole cell pertussis vaccine like pain, swelling at the site of injection, fever, vomiting anorexia, persistent crying & drowsiness have been the cause of great concern, till date. Also the safety conc...

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN

The potency, toxicity and immunogenicity of glutaraldehyde inactivated pertussis vaccine

Whole cell pertussis vaccine was prepared by inactivation of Bordetella pertussis organisms with glutaraldehyde under optimal conditions (0.05% glutaraldehyde at room temperature for 10 minutes). This glutaraldehyde inactivated pertussis vaccine-1 (GIPV-1) was compared to the routinely produced heat inactivated (56°C for 30 minutes) pertussis vaccine (HIPV) for potency, toxicity and immunogenic...